Seung Wook Oh, Ph.D. Executive Director / Principal Scientist
- Dr. Oh is a devoted biomedical researcher with broad interests in neurobiology, ranging from studying neurodegenerative diseases and molecular mechanism of aging, to regulation of feeding and lipid metabolism by brain. His current research goal is to help decipher the overwhelming complexity of the human brain and eventually develop better therapeutics for various brain disorders, with a focus on systematic approach combining advanced molecular and genetic techniques with high-throughput technology.
- He was instrumental in the development of the Allen Mouse Brain Connectivity Atlas, a groundbreaking public database that describes for the first time how the mammalian brain is wired in detail. As a lead scientist and scientific program manager, Dr. Oh led interdisciplinary teams to build this landmark public resource at the Allen Institute, from developing scientific strategies, building data production pipelines and leading data analysis. He also demonstrated his management skills in several other brain mapping or grant research projects funded by NIH, NSF and HFSP.
- Currently, he is organizing an effort to accelerate disease research and drug development by inspiring and helping others to maximize the benefits of Big Science at Grace Medical Institute.
- B.S., Chemistry, Seoul National University, Seoul, Korea
- M.S., Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Korea
- Ph.D., Biomedical Sciences, University of Massachusetts Medical School, Worcester, MA
- Oh SW, Harris JA, Ng LL, Winslow B, Cain N, Mihalas S, Wang Q, Lau C, Kuan L, Henry AM, Mortrud MT, Ouellette B, Nguyen TN, Sorensen SA, Slaughterbeck CR, Wakeman W, Li Y, Feng D, Ho A, Nicholas E, Hirokawa KE, Bohn P, Joines KM, Peng H, Hawrylycz MJ, Phillips J, Hohmann JG, Wohnoutka P, Gerfen CR, Koch C, Bernard A, Dang C, Jones AR, Zeng H. A mesoscale connectome of the mouse brain. Nature 508: 207-214 (2014).
- Zeng H, Shen E, Hohmann JG, Lein ES, Oh SW, Bernard A, Sunkin SM, Guillozet-Bongaarts AL, Royall JJ, Swanson B, Kuan L, Overly CC, Hawrylycz MJ, Hof PR, Hyde TM, Kleinman JE, and Jones AR. Large-scale cellular-resolution gene profiling in human neocortex reveals species-specific molecular signatures. Cell 149(2): 483-496 (2012).
- Madisen L, Zwingman TA, Sunkin SM, Oh SW, Zariwala HA, Gu H, Ng LL, Palmiter RD, Hawrylycz MJ, Jones AR, Lein ES, and Zeng H. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nature Neuroscience 13(1): 133-142 (2010).
John A. Morris, Ph.D. Principal Scientist
- Dr. Morris revels in the application of translational neuroanatomy within the context of neuroendocrinology, toxicity, and pharmacology, by applying technological efficiencies of scale. He is also enthusiastic about applying and sharing expert knowledge in data creation, interpretation, and communication, which culminated with the design and success of the first molecular neuroanatomy workshop at the Okinawa Institute of Science and Technology, Japan.
- During his 8 year tenure at the Allen Institute for Brain Science, he participated in constructing pioneering the Allen Brain Atlas as a molecular neuroanatomist, specifically for the developmental mouse and the adult human atlases along with other large projects considering the effect of strain, species, and sex on gene expression of drug targets. Dr. Morris trained the data annotation team in comparative molecular neuroanatomy and led their efforts across many atlas and data analysis projects. Following the completion of atlas projects, Dr. Morris moved to the preclinical environment and directed GLP studies at SNBL USA, where specialization in non-human primate work has provided him means to develop new ways of measuring drug efficacy and safety.
- His experience regarding safety pharmacology alerted him to a surprising gap, whereby unexpected neurological side effects could be anticipated or mitigated by applying translational brain mapping experience to such preclinical concerns. Currently, Dr. Morris is applying his expertise in CNS specific data sets, brain maps, to exploit translational potentials of many drug targets much earlier in the discovery process.
- B.S., Economics and Psychology, University of Tennessee, Knoxville, TN
- Ph.D., Neuroscience, Michigan State University, East Lansing, MI
- Morris JA, Royall JJ, Bertagnolli D, Boe AF, Burnell JJ, Byrnes EJ, Copeland C, Desta T, Fischer SR, Goldy J, Glattfelder KJ, Kidney JM, Lemon T, Orta GJ, Parry SE, Pathak SD, Pearson OC, Reding M, Shapouri S, Smith KA, Soden C, Solan BM, Weller J, Takahashi JS, Overly CC, Lein ES, Hawrylycz MJ, Hohmann JG, Jones AR. Divergent and non-uniform gene expression patterns in mouse brain. PNAS 107(44):19049-19054 (2010).
- Hawrylycz MJ, Lein ES, Guillozet-Bongaarts AL, Shen EH, Ng L, Miller JA, van de Lagemaat LN, Smith KA, Ebbert A, Riley ZL, Abajian C, Beckmann CF, Bernard A, Bertagnolli D, Boe AF, Cartagena PM, Chakravarty MM, Chapin M, Chong J, Dalley RA, Daly BD, Dang C, Datta S, Dee N, Dolbeare TA, Faber V, Feng D, Fowler DR, Goldy J, Gregor BW, Haradon Z, Haynor DR, Hohmann JG, Horvath S, Howard RE, Jeromin A, Jochim JM, Kinnunen M, Lau C, Lazarz ET, Lee C, Lemon TA, Li L, Li Y, Morris JA, Overly CC, Parker PD, Parry SE, Reding M, Royall JJ, Schulkin J, Sequeira PA, Slaughterbeck CR, Smith SC, Sodt AJ, Sunkin SM, Swanson BE, Vawter MP, Williams D, Wohnoutka P, Zielke HR, Geschwind DH, Hof PR, Smith SM, Koch C, Grant SG, Jones AR. An anatomically comprehensive atlas of the adult human brain transcriptome. Nature 489(7416):391-9 (2012).
- Zeng H, Shen EH, Hohmann JG, Oh SW, Bernard A, Royall JJ, Glattfelder KJ, Sunkin SM, Morris JA, Guillozet-Bongaarts AL, Smith KA, Ebbert AJ, Swanson B, Kuan L, Page DT, Overly CC, Lein ES, Hawrylycz MJ, Hof PR, Hyde TM, Kleinman JE, Jones AR. Large-scale cellular-resolution gene profiling in human neocortex reveals species-specific molecular signatures. Cell 149(2): 483-496 (2012).